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Wei-Jen Tang Selected Research

Insulysin (Insulin-Degrading Enzyme)

1/2018Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.
1/2018Catalytic Mechanism of Amyloid-β Peptide Degradation by Insulin Degrading Enzyme: Insights from Quantum Mechanics and Molecular Mechanics Style Møller-Plesset Second Order Perturbation Theory Calculation.
1/2016Targeting Insulin-Degrading Enzyme to Treat Type 2 Diabetes Mellitus.
9/2015Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice.
2/2011Ubiquitin is a novel substrate for human insulin-degrading enzyme.
1/2010Molecular basis for the recognition and cleavages of IGF-II, TGF-alpha, and amylin by human insulin-degrading enzyme.
11/2008Immunohistochemical evidence of ubiquitous distribution of the metalloendoprotease insulin-degrading enzyme (IDE; insulysin) in human non-malignant tissues and tumor cell lines.
10/2008Expression of metalloprotease insulin-degrading enzyme insulysin in normal and malignant human tissues.
8/2007Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE.
8/2007The amino terminus of varicella-zoster virus (VZV) glycoprotein E is required for binding to insulin-degrading enzyme, a VZV receptor.

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Wei-Jen Tang Research Topics

Disease

23Anthrax
01/2019 - 01/2002
10Edema (Dropsy)
01/2019 - 04/2005
9Alzheimer Disease (Alzheimer's Disease)
12/2019 - 08/2007
6Whooping Cough (Pertussis)
04/2012 - 12/2002
6Infections
12/2010 - 08/2004
4Inflammation (Inflammations)
01/2018 - 04/2008
3Neoplasms (Cancer)
11/2008 - 02/2004
2Disease Progression
01/2021 - 10/2016
2Glucose Intolerance
09/2015 - 10/2006
1Tuberculosis (Tuberculoses)
01/2021
1Nervous System Diseases (Neurological Disorders)
12/2019
1B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)
10/2016
1Leukemia
10/2016
1Type 2 Diabetes Mellitus (MODY)
01/2016
1Neuroblastoma
05/2014
1Diabetes Mellitus
05/2010
1Toxemia
03/2009
1Breast Neoplasms (Breast Cancer)
10/2008
1Ovarian Neoplasms (Ovarian Cancer)
10/2008
1Pulmonary Edema
06/2008
1Lymphopenia (Lymphocytopenia)
06/2008
1Shock
06/2008
1Hemorrhage
06/2008
1Hypotension (Low Blood Pressure)
05/2007
1Chronic Hepatitis B
03/2004
1Persistent Infection
03/2004
1Carcinogenesis
02/2004
1Necrosis
02/2004

Drug/Important Bio-Agent (IBA)

18Adenylyl Cyclases (Adenylyl Cyclase)IBA
07/2015 - 01/2002
13edema factorIBA
07/2015 - 12/2002
10Insulysin (Insulin-Degrading Enzyme)IBA
01/2018 - 08/2007
8Calmodulin (Calcium-Dependent Activator Protein)IBA
07/2015 - 01/2002
6anthrax toxin (anthrax lethal factor)IBA
01/2019 - 03/2004
6ExotoxinsIBA
01/2019 - 01/2002
6Peptides (Polypeptides)IBA
01/2018 - 08/2007
6Virulence Factors (Pathogenicity Factors)IBA
04/2012 - 03/2004
5Insulin (Novolin)FDA Link
01/2018 - 08/2007
5AntigensIBA
11/2010 - 02/2005
4EnzymesIBA
01/2021 - 10/2008
4Metalloproteases (Metalloproteinases)IBA
01/2021 - 08/2007
4Amyloid (Amyloid Fibrils)IBA
01/2018 - 02/2011
4Amyloid beta-PeptidesIBA
05/2014 - 10/2006
4Proteins (Proteins, Gene)FDA Link
04/2012 - 05/2007
4CytokinesIBA
06/2008 - 03/2004
3Pharmaceutical PreparationsIBA
05/2007 - 03/2004
2ZincIBA
01/2021 - 08/2007
2Adenylate Cyclase ToxinIBA
04/2012 - 12/2009
2purineIBA
08/2009 - 03/2009
2Pyrimidine NucleotidesIBA
08/2009 - 03/2009
2Anti-Bacterial Agents (Antibiotics)IBA
03/2009 - 06/2008
2Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
04/2005 - 02/2004
1Neutralizing AntibodiesIBA
01/2019
1Agammaglobulinaemia Tyrosine KinaseIBA
10/2016
1ibrutinibIBA
10/2016
1Phosphotransferases (Kinase)IBA
10/2016
1CC ChemokinesIBA
05/2016
1LigandsIBA
05/2016
1ChemokinesIBA
12/2010
1Macrophage Inflammatory Proteins (Macrophage Inflammatory Protein 1)IBA
12/2010
1Peptide Hormones (Polypeptide Hormones)IBA
05/2010
1Glucose (Dextrose)FDA LinkGeneric
05/2010
1CholesterolIBA
05/2009
1PerforinIBA
05/2009
1Hemoglobins (Hemoglobin)IBA
06/2008
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
04/2008
1G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA
04/2008
1Glycoproteins (Glycoprotein)IBA
08/2007
1erythromycin propionate-N-acetylcysteinateIBA
07/2007
1Interleukin-10 (Interleukin 10)IBA
04/2005
1Antigen Receptors (Antigen Receptor)IBA
02/2005
1Indicators and Reagents (Reagents)IBA
08/2004
1diphosphoric acid (pyrophosphoric acid)IBA
07/2004
1adefovir dipivoxil (Hepsera)FDA Link
03/2004
1adefovirIBA
03/2004
1NF-kappa B (NF-kB)IBA
02/2004
1AntitoxinsIBA
07/2003
1factor AIBA
01/2002

Therapy/Procedure

3Therapeutics
01/2019 - 02/2004
1Intravenous Infusions
05/2007